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KMID : 1143420160090010002
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Public Health Weekly Report
2016 Volume.9 No. 1 p.2 ~ p.7
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Current status of studies regarding endothelial cell dysfunction for the prevention, management and treatment of vascular diseases in Korea
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Park Hyun-Young
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Abstract
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Background: Vascular endothelial cells line the entire circulatory system and maintain the vascular tone and blood fluidity. Endothelial dysfunction plays a critical role in the development of various human diseases including atherosclerosis. Since the recognition of endothelial cell physiology, many studies have been conducted to understand the relationship between endothelial cell dysfunction and vascular diseases.
Current status: Previous studies identified several risk factors of vascular diseases. Oxidized low density lipoprotein and inflammatory cytokines induce vascular inflammation, as well as endothelial cell apoptosis. Advance glycosylation end products generated by glycosylation of protein or lipid in hyperglycemic environment contribute to the development of vascular diseases in diabetics.
Recent : studies showed that disturbed blood flow is a critical factor of endothelial dysfunction in atherosclerosis. We have identified that the coronin 1A protein is expressed in endothelial cell and regulates the tumor necrosis factor α-induced endothelial cell apoptosis by modulating the expression of p38β.
Prospective future: Considering that Korea is projected to become a super-aged society and expected to suffer from ageing-related diseases, it is important to reduce the vascular risk factors and maintain healthy blood vessels. Therefore, studies on how to prevent, manage and overcome vascular diseases should be continued.
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KEYWORD
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